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What is the difference between metformin and sitagliptin?

What is the difference between metformin and sitagliptin?

What is the difference between metformin and sitagliptin?

Metformin works by decreasing glucose (sugar) production in the liver and decreasing absorption of glucose by the intestines. Sitagliptin works by regulating the levels of insulin your body produces after eating.

What is the side effect of sitagliptin?

The most common side effects of JANUVIA include upper respiratory infection, stuffy or runny nose and sore throat, and headache. JANUVIA may have other side effects, including stomach upset and diarrhea, swelling of the hands or legs, when JANUVIA is used with metformin and rosiglitazone (Avandia ®).

Which class of drug is sitagliptin?

Sitagliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the amounts of certain natural substances that lower blood sugar when it is high.

Why sitagliptin is used with metformin?

Sitagliptin + Metformin is a combination of two antidiabetic medicines: Sitagliptin and Metformin. They help your pancreas produce more insulin, facilitate effective use of insulin by the body, and reduce excess sugar that your liver makes. Together, they provide better control of blood sugar.

Can I take sitagliptin and metformin together?

If you are taking 8 mg of immediate-release metformin 2 times per day, you may start with two 50 mg sitagliptin tablets and 1000 mg of metformin taken together once a day. Children—Use and dose must be determined by your doctor.

Is Januvia bad for your kidneys?

Kidney effects No clinical studies have linked the use of Januvia to kidney problems. But some people have reported kidney problems after taking Januvia, including kidney failure.

Is sitagliptin bad for kidneys?

Conclusions: Impaired kidney function is associated with worse cardiovascular outcomes. Sitagliptin has no clinically significant impact on cardiovascular or CKD outcomes, irrespective of baseline eGFR.

Who should not take sitagliptin?

It shouldn’t be used in children younger than 18 years. As you age, your kidneys may not work as well as they once did. Your dosage of sitagliptin will depend on your kidney function. Your doctor will check your kidneys before and during treatment with this medication.

Can I take metformin and linagliptin together?

The addition of linagliptin to metformin in a loose-pill combination (LPC) has provided better glycemic control than monotherapy with either metformin or linagliptin alone. Linagliptin, like other DPP-4 inhibitors, is available as a single-pill combination (SPC) with metformin.

What is the best time to take sitagliptin?

Take sitagliptin once a day. You can take it at any time – for example, in the morning or in the evening. Just try to take it at the same time every day. Take your tablet with a glass of water.

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